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Professional research paper about periowave

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Research paper about periowave

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About Periowave™

Periowave™ uses the powerful photodisinfection reaction to demobilize the bacteriums and toxins that are left behind after scaling and root planing. First, a little measure of blue-coloured photosensitizer solution is locally applied to the gums at the intervention site where it attaches to microbes and toxins associated with gum disease. Second, a thin, fictile visible radiation usher is painlessly placed into the intervention site. The light usher illuminates the intervention site with a specifically calibrated optical maser visible radiation, triping the photosensitizer solution and destructing bacteriums beneath the gum line. Each intervention site requires merely 60 seconds of optical maser activation, doing it a speedy, painless process.


Periowave is an antimicrobic photodynamic therapy ( a-PDT ) machine. It is used in periodontias, endodontias and operative dental medicine to kill bacteriums or suppress the growing of bacteriums ( e.g. Porphyromonas gingivalis ) . Antimicrobial photodynamic therapy is the procedure in which visible radiation and photosensitizer are used to destruct cell membrance of the bacteriums by the action of reactive O species and vest O. Professor Michael Wilson of University College London is the innovator of photodisinfection or a-PDT which is a non-invasive, non-antibiotic and non-surgical process. The Periowave aPDT system was introduced to the market by Ondine Biomedical Inc. , Vancouver B.C. in 2006. Periowave is approved for the intervention of chronic periodontal disease, gingivitis, endodontias, and peri-implantitis disease.

Periowave: A New Treatment for Periodontal Disease

Ondine´s proprietary intervention, Periowave uses a fresh non-antibiotic attack for handling the implicit in infection responsible for periodontic disease. After everyday grading, the tooth doctor will use the compound straight into the periodontic pockets and around the gum line of affected dentitions. The compound rapidly penetrates the plaque preferentially adhering to multiple structural constituents in bacteriums, including their toxic secernments. Laser visible radiation is so applied straight to the affected sites utilizing a fibre ocular investigation. A powerful free-radical reaction destroys the targeted bacteriums and the associated toxins such as collagenase. The process is expected to take under 20 proceedingss to finish for the full oral cavity. Little or no hurting will be involved, a important advantage over current traditional interventions. Additionally, interventions will by and large be administered by hygienists.

5 ideas on “Periowave: A New Treatment for Periodontal Disease”

I looked at the company’s web site. The pilot survey that led to blessing was 9/05 but I don’t see anyplace that even the abstract was published. There’s no statistics in the imperativeness release–just things like 155 % better, but I can’t state if that’s 1mm V 1.4 millimeter or what. It’s besides a small funny that it’s been 1 1/2 old ages and I’ve ne'er even heard of it. They compared it to SRP but I’d like to see what SRP plus the optical maser did compared to their photoactive solution with SRP and the optical maser. The biological science makes some sense, but it will still hold the job of the optical maser making every bacterial cell to be genuinely bacteriocidal.

This is so interesting…..Kill the bugs and halt the disease. I am certain we all understand that the host opposition is the key. There are patients, no affair what you do, the bone goes off. The inquiry for me has ever been…even with perfect plaque control unless the pockets are disinfected..bone loss. All companies…Perio Chip et all are contending at the pocket degree. The patients are immune to speaking Periostat, Doxy for long periods and surely the vitamin thing is non making it. I for one are really interested in more information. Has anyone placed Arestine around the cervix part of the implant are clip of arrangement with a healing abutment through the tissue or immediate burden?

What do infective bacteriums in your oral cavity have to make with malignant neoplastic diseases in your GI piece of land?

But we’re non quite at that place yet. In the interim, the JAMA study observes, “although the NYU … survey consequences are challenging, it’s excessively shortly to urge that people step up their brushing and flossing as a preventative measure.” Maybe so, but until the finding of fact is in we might be cautioned to take our cue from Pascal’s Wager. The 17th C French philosopher Blaise Pascal argued that it’s best to populate your life as if God exists because if you’re right, the wages is enormous — you go to heaven ; but if you’re incorrect, there’s truly no downside. Similarly, by populating your life as if good unwritten hygiene can avoid a battalion of GI piece of land malignant neoplastic diseases, the wages is besides enormous — a healthy life ; but even if you’re incorrect, what’s the downside?

2014 Dental Mission to Yucatan Mexico – 755 Patient Treatments

Led by the spirited Dr. Veronique Benhamou, Head of Periodontology of McGill University, the Canadian alveolar consonant squad completed another successful dental mission in the Yucatan. This 2014 trip was the team’s 2nd clip in Mexico supplying Mayans populating in distant parts of the Yucatan, with entree to universe category dental medicine. More than 750 patients were treated during this 10 twenty-four hours “Kindness in Action” mission. The squad of 22 consisted of McGill dental pupils, volunteering tooth doctors mostly from the Montreal country, and voluntaries from companies in the dental industry including 3 from Periowave Dental Technologies Inc.

This mission was facilitated by support from Mexicans from the Yucatan, Guadalajara and Mexico City. Captain Carlos Erosa, city manager of Espita and local business communities including Professor Montforte, Alfonso Salazar and Gabriel Domenzain provided aid with logistics, equipment every bit good as the proviso of local installations. The joint attempt produced a great experience for all involved and most significantly, resulted in a really big figure of under-privileged people in the distant country of Espita Yucatan obtaining the alveolar consonant attention that they desperately needed. Dr. Miguel de la Isla, Guadalajara-based President of the Mexican Periodontology Association ( AMP ) participated in this year’s dental mission, volunteering his clip and dental supplies to help alongside the Canadian squad.

Dental Students are at Risk for Increased Exposure to MRSA: What does this mean for their Patients?

Dental pupil are at a much greater hazard of being exposed to methicillin-resistant Staphylococcus aureus ( MRSA ) , the potentially deadly bacteriums frequently found in infirmaries and now progressively in the general community. Known as one of the superbugs due to its ability to defy multiple antibiotics, the mortality rate for a MRSA blood stream infection is about 20-30 % .1 The findings of a late published survey in The Journal of Hospital Infection entitled “Higher prevalence of methicillin-resistant Staphylococcus aureus among dental students” hypertext transfer protocol: //www.journalofhospitalinfection.com/article/S0195-6701 ( 14 ) 00009-7/abstract lead to the inevitable decision that greater consideration for infection control and bar is needed for both dental clinicians and their patients.

The survey undertaken in Mexico City comparing 100 dental pupils ( exposed to patients for 5-6 old ages ) with 81 non-dental pupils found that the dental pupils had a significantly higher rate of passenger car of MRSA. The survey found that 20 % of the dental pupils versus 6 % of non-dental pupils were colonized with MRSA ( odds ratio: 4.04 ; 95 % assurance interval: 1.6–12.6 ; P = 0.0033 ) . The decision of the survey is that the dental pupils were occupationally threatened by exposure to this extremely antibiotic resistant pathogen with deductions that greater stairss are needed to seek to turn to this possible hazard to their wellness. The other unreassuring deduction of this survey is that these dental clinicians are besides likely to be vectors for MRSA transmittal to their patients if the proper safeguards are non undertaken.

Until late, most antibiotics in Mexico were available over the counter and non by prescription. The ability of patients to self-prescribe ( non fiting the appropriate antibiotic to the prevalent infection ) combined with standard non-compliance patterns ( taking sub-lethal doses ) led to the outgrowth of high antibiotic opposition rates as evidenced by the determination of this survey. Fortunately, there are greater controls over how antibiotics are now dispensed in Mexico which should assist to take down antibiotic opposition rates in the Mexican populace in the hereafter. A decrease of the overexploitation and maltreatment of antibiotics in Mexico should, in the hereafter, contribute to take downing the hazard of MRSA colonisation in the dental clinician population. In the interim, nevertheless, the consequences of this survey are flooring and must be taken as mark that more must be done to protect the dental clinician and their patients from this potentially deathly superbug.

Periowave: A Unique Anti-Inflammation Therapy that Yields Superior Patient Outcomes

It is widely understood that chronic periodontitis is due to the presence of subgingival Gram-negative bacterial biofilms proliferating at the junctional epithelium, in periodontal pockets deep beneath the gumline. Mechanical debridement (scaling) and root planing (SRP) is standard therapy for chronic periodontitis. While SRP is useful for the removal of the calculus, SRP unfortunately leaves the majority of the Gram-native biofilm in the periodontal pocket resulting in the need for retreatment every 3 months to control the disease. SRP alone is often inadequate for very deep pockets, for instance pockets that are 10-13 millimetres deep. Patients with deep periodontal pockets typically are referred to specialists for surgical intervention, especially when bone loss is evident. Photodisinfection is a non-antibiotic, light based therapy that offers a non-invasive alternative to surgery. Photodisinfection has been shown to instantly inactivate the Gram-negative bacteria associated with periodontal diseases, as well as the bacterial virulence factors responsible for triggering inflammation. The key virulence factors of P. gingivalis (a primary perio-pathogen) include the cytotoxin lipopolysaccharide (“bacterial endotoxin or LPS”), proteolytic enzymes and many toxic low-molecular weight compounds such as hydrogen sulfide and ammonia. The proteases in particular are thought to be responsible for the majority of periodontal tissue damage. Photodisinfection destroys the LPS and other virulence factors, a significant advantage over conventional antibiotics and antiseptics. Periowave Photodisinfection, more importantly, offers a key advantage over other therapies as it was able to demonstrate direct and immediate inactivation pro-inflammatory cytokines. The Periowave Photodisinfection approach can directly inhibit LPS, reducing the risk of cytotoxic shock, and can substantially reduce protease activity, minimizing the risk of further tissue damage. Periodontal (gum) disease is a chronic disease affecting about half the adult population. It is the leading cause of tooth loss, responsible for about two thirds of lost teeth. Pain and cost factors result in the majority of diagnosed patients neglecting to address their gum disease. Periowave Photodisinfection technology, with its unique ability to simultaneously eliminate the underlying bacteria causing chronic gum disease as well as reduce inflammation, is an important stress free therapy benefitting both the patient and the dental clinician. Periowave is a cost effective and pain-free approach to the treatment of gum disease, whether as a prevention therapy in early stages of the disease or as a possible alternative to surgery in later stages of the disease. Irrigate Illuminate To learn more about Periowave Photodisinfection, please visit www.periowave.com

Periowave Photodisinfection- The Unique 3 Prong Attack on Periodontal ( Gum ) Disease

Gum disease is caused by the presence of Gram-negative bacterial biofilms turning in the periodontic pockets underneath the gum line. These gram- negative pathogens associated with gum disease are mostly anaerobiotic, booming in environments with small to no O. Bacteria, and their associated virulency factors, cause an immune response by the organic structure. Gram negative pathogens associated with gum disease are non “good” bugs ( commensals ) , that is, they are non portion of the body’s natural vegetation. One pathogen, Porphyromonas gingivalis, harmonizing to Dr. Richard Darveau, Dean of the University of Washington’s Dental School, has demonstrated an ability to modify the behavior of unwritten commensals, turning bacteriums that are usually ‘good’ bacteriums into ‘bad’ . Perio-pathogens, such as Porphyromonas gingivalis, up-regulate the body’s production of proteolytic enzymes, cytokines and other proinflammatory factors in order to prolong their continued growing. The consequence is redness with widespread impact on the local every bit good as systemic physiology.

Gum disease has been associated with a figure of serious systemic conditions including bosom disease, shot, diabetes, pre-diabetes, malignant neoplastic disease, Alzheimer’s and pre-term births. The most noteworthy local symptoms of the effects of these perio-pathogens are ruddy inflamed gums and the loss of alveolar bone back uping the dentition. Gum disease is responsible for about two tierces of tooth loss. Scaling and root planing ( SRP ) , the historic criterion of attention leaves every bit much as 60 % of the perio-pathogens behind to go on the disease procedure, which is why the SRP protocol requires a 3 month retreatment callback plan. Photodisinfection, nevertheless, has been able to duplicate the results of SRP in clinical tests.

Effective gum disease obliteration requires 3 constituents which merely Periowave Photodisinfection provides: the instantaneous riddance of virtually all of the gm negative anaerobiotic perio-pathogens, the devastation of their associated virulency factors, and the inactivation of the host inflammatory factors. When taking both the biofilm and the redness at the same time, the organic structure is so able to mend itself through soft and difficult tissue regeneration. Periowave Photodisinfection has been proven to quickly and efficaciously kill the micro-organisms located in periodontic biofilms and to destruct the virulency factors produced by these pathogens. Most significantly, Periowave has a alone advantage, an ability to quickly and well cut down peptidase activity, supplying a high-ranking suppression of proinflammatory cytokines needed to reconstruct unwritten wellness.

Photodisinfection is a topical, non-antibiotic antimicrobic therapy that destroys a wide spectrum of pathogens including Fungi, bacteriums and virus without damaging human tissue. Unlike antibiotics, Photodisinfection selectively kills virulency factors such as the endotoxins and exotoxins produced by pathogens, taking to a clinically discernible anti-inflammatory consequence. The intervention procedure takes merely proceedingss, doing it over 1,000 times more effectual at biofilm killing than antibiotics.

Photodisinfection is a minimally invasive non-thermal therapy affecting the light activation of a photosensitizer to extinguish topical infections in a extremely targeted attack. Photodisinfection has been proven to be safe and effectual in other applications such as for the alveolar consonant, sinusitis and infirmary acquired infection bar markets. In dental medicine, Photodisinfection has been proven to be extremely effectual for the intervention of cavities, endodontias, renewing dental medicine, periodontal disease, peri-implantitis and halitosis. Many new applications of Photodisinfection are now under development.

Head of McGill’s Periodontal Department Recipient of Humanitarian Award from Mexican Periodontal Association ( AMP )

Leading a little squad of pupils, instructors and alumnas of McGill University, Dr. Benhamou was responsible for supplying dental attention to over 700 Mayan patients in the Yucatan, an country of Mexico with limited chances for dental attention. This mission to Espita, Mexico is one of over a twelve such missions led by Dr. Veronique Benhamou to underprivileged parts and Developing Nations. Dr. Benhamou and her squad program to return to Espita in January 2014 for another mission of dental attention. Periowave Dental Technologies wishes to compliment Dr. Benhamou for her well-deserved acknowledgment at the AMP.

What is the Perio Tray?

The prescription Perio Tray is customized for single patients with an internal seal that helps put medicine deep below the gums so that the medicine can contend the infective bacteriums. This is of import because brushing, rinse, and flossing merely can’t range below the gums to pull off the bacteriums that cause the disease. You can’t cure gum disease but you need to pull off it good or the bacteriums will recolonize and go on the disease rhythm. The Perio Tray was created to acquire medication deep beneath the gums and keep it at that place long plenty to contend the bacterial communities ( called biofilms ) . The Perio Tray is a alone prescription medical device that is used under the supervising of a dental professional for more effectual and long-run gum disease intervention. The laminitis and Chief Scientific Officer of Perio Protect has a personal history that inspired the creative activity of the Perio Tray, and he has made it his mission to distribute this less-invasive gum disease intervention option to as many patients as possible.

At Home Oral Bacteria Management

Pull offing unwritten bacteriums that cause gum diseases is an of import portion of keeping unwritten wellness, every bit good as your overall wellness. The Perio Tray is instrumental in assisting patients pull off their gingivitis or periodontal disease, supplying daily, effectual therapy that actively fights bacteriums buildups and supports bacteriums from distributing. Oral bacteriums direction can advance your general health excessively because the unwritten bacteriums that cause gingivitis and periodontal disease gum diseases are linked to several other serious systematic diseases, including type 2 diabetes, bosom disease, shots, and more. To better your overall wellness, be certain to pull off your gum disease with proper dental hygiene, which includes on a regular basis scheduled professional dental cleansings and the prescription Perio Tray between office visits.

Periowave™ Is Coming Ashore

One of the high spots of the RDH Under One Roof 2007 conference in Washington, D.C. , was acquiring to pass clip with friends, and one in peculiar comes to mind. Catherine Fairfield, RDH, and I co-presented on periodontic biofilms at UOR, and we were able to pass some quality clip together after our presentation was over. Catherine is a Canadian who lives in Calgary, where she patterns dental hygiene full clip and Teachs portion clip as a clinical pedagogue in alumnus periodontic surveies at the University of British Columbia. Catherine and I are periodontic swots, and we are happy when we are discoursing periodontic pathogens, advanced instrumentality, or disinfecting periodontic pockets. On the goad of the minute, we decided to tour Georgetown and rapidly settled in at a nice eating house where we pored over the latest issue of a peer-reviewed periodontic diary. How many hygienists do you cognize who are “nerdie” plenty to be happiest nibbling on a salad while discoursing the latest research literature environing the function of A. actinomycetemcomitans in periodontic infections?

Antimicrobial photodynamic therapy has been used in medical specialty by uniting a atoxic photoactive dye or photosensitizer with harmless seeable visible radiation to kill micro-organisms, barms, and even viruses. A professor at the Eastman Dental Institute, University College London, England, named Michael Wilson foremost proposed the usage of photosensitization for the nonsurgical intervention of periodontic diseases in 1989. The photosensitizer in the Periowave™ intervention kit used to zap periodontic pathogens is methylene blue, and it is applied straight into the pocket with a blunt irrigation acerate leaf to the vertex of the pocket. Next, a rectifying tube optical maser ( Periowave™ ) attached to a fiberoptic overseas telegram, handpiece, and light-diffusing tip that is shaped like a periodontic investigation illuminates the pocket and activates the photosensitizing agent.

When did you foremost acquire introduced to Periowave™ and are you utilizing it routinely in clinical pattern?

Clinical test consequences to date1 that have compared SRP entirely to SRP with photodisenfection have been overpoweringly positive. Our office has had really positive clinical consequences, but as with all adjunctive therapies, my consequences do non ever supply the “answer” that I would wish. We must retrieve as clinicians that this merchandise was designed as an adjunctive therapy to thorough mechanical debridement. In other words, there are farther clinical parametric quantities and single patient conditions that do non let this process to be the Panacea that we all dream of. Periowave™ is a fantastic noninvasive, nonantibiotic first intervention option as an LDA to attach to thorough nonsurgical intervention.

My most memorable Periowave™ instance will ever be my first instance. This immature adult female, 13 old ages old, presented with an stray perpendicular defect with 7 millimeters examining deepness ( PD ) and shed blooding on examining ( BOP ) on the mesial of her first lower left grinder. Initial therapy, dwelling of full-mouth debridement with local anaesthesia for the lower left quadrant, resulted in PD and BOP staying unchanged. A three-month periodontic care agenda was introduced with one class of systemic Amoxil ( 250 milligram ) and Flagyl ( 250 milligram ) three times daily ( TID ) for seven yearss as recommended by the periodontist. Clinical findings were unchanged at the subsequent three-month PM, at which clip SRP was performed followed by the same systemic antibiotic regimen as earlier.

Based on grounds, do you believe that debriding and disinfecting pockets is better than debriding entirely?

There is decidedly grounds back uping uniting debridement and disinfection subgingivally to supply more comprehensive intervention for patients demoing marks of redness or infection. Drisko recommends that mechanical and chemotherapeutic attacks be utilized to minimise or extinguish microbic biofilm both supra and subgingivally. This anti-infective therapy is surely warranted in instances that have non shown clinical betterments such as decreased PD and most significantly, reduced BOP with mechanical debridement entirely. There is besides grounds bespeaking that bacteriums such as Pg and Aa are non wholly removed with conventional mechanical instrumentality entirely, and farther grounds shows that these putative pathogens are capable of occupying host cells, which may take to recurrent periodontic diseases or furnace lining periodontic diseases.

Have you of all time used other local bringing antimicrobic agents ( LDAs ) like Arestin® , Atridox® , or PerioChip® ?

Atridox® is the merely other LDA, other than chlorhexidine gluconate or CHX, available in Canada. I have had limited usage with Atridox® in the yesteryear, and it was utilized merely locally in unresponsive sites, after initial therapy or after the re-evaluation or at subsequently times in perennial periodontic disease sites. The troubles with Atridox were chiefly in the bringing system, as it was gluey and hard to present to the base of the pocket. Our consequences were assorted, as with many LDAs, with some sites reacting favourably and others non so, which may be due to many factors such as bringing, entree, and the form and size of the periodontic defect. I have ne'er been concerned about extra costs for any intervention, as our intervention is recommended based on clinical/radiographic findings, scientific discipline, and practicality for each single patient with his/her best involvement at the centre of all intervention determinations.

How does Periowave™ differ from other LDAs?

The bringing of Periowave™ is different from other local bringing agents ( LDAs ) as it is a simple two-step process in which the photodisinfection solution is irrigated into the specific site with a blunt-ended cannula, and so instantly illuminated for 60 seconds with a nonthermal rectifying tube optical maser visible radiation. This specific light wavelength is designed to trip the proprietary Periowave™ solution, extinguishing the putative pathogens and virulency factors within the 60-second clip frame. The ability of the solution and visible radiation to entree difficult-to-reach countries, such as concave shapes, forkings, and the deepest parts of the pocket are seen as advantages over other LDAs.

About the Writer

Lynne H. Slim, RDH, BSDH, MSDH, is a practicing hygienist/periodontal healer who has more than 20 years’ experience in both clinical and educational scenes. She is besides president of Perio C Dent Inc. ( Perio-Centered Dentistry ) , a practice-management consulting house that specializes in making outstanding dental hygiene squads. Lynne is a member of the Speaking and Consulting Network ( SCN ) that was founded by Linda Miles, and has won two first-place news media awards from ADHA. Lynne is besides owner/moderator of a periodontic healer yokel group: hypertext transfer protocol: //yahoogroups.com/group/periotherapist. She can be contacted at periocdent @ mindspring.com.

Periowave, photodynamic disinfection. Periogen, dissolves concretion?

Although the ground why fossilized bacteriums are attracted to one portion of the subgingival tooth surface, and non another, is non to the full understood ; one time the first bed is attached, ionised concretion constituents are of course attracted to the same topographic points due to electrical charge. The fossilised bacteriums pile on top of one another, in a instead hit-or-miss mode. All the piece, free-floating ionic constituents make full in the spreads left by the fossilised bacterium. The end point hardened construction can be compared to concrete ; with the fossilised bacteriums playing the function of sum, and the smaller Ca phosphate salts being the cement. The one time strictly electrical association of fossilized bacteriums so becomes mechanical, with the debut of free-floating Ca phosphate salts. The “hardened” concretion formations are at the bosom of periodontic disease and intervention.

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